TTC3 - tetratricopeptide repeat domain 3 Gene

Also Known as DCRR1; RNF105; TPRDIII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7267

About TTC3

Cytogenetic location: 21q22.13 Genomic coordinates (GRCh38): 21:37,073,254-37,203,118 (from NCBI)

This gene has 26 transcripts (splice variants) and 233 orthologues. Ubiquitous expression in brain (RPKM 28.4), thyroid (RPKM 22.3) and 25 other tissues.

Summary

Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TTC3 Products (10)

mRNA Protein Name
NM_001001894.3 NP_001001894.1 E3 ubiquitin-protein ligase TTC3 isoform 1
NM_001320703.2 NP_001307632.1 E3 ubiquitin-protein ligase TTC3 isoform 3
NM_001320704.2 NP_001307633.1 E3 ubiquitin-protein ligase TTC3 isoform 2
NM_001330681.2 NP_001317610.1 E3 ubiquitin-protein ligase TTC3 isoform 4
NM_001330682.2 NP_001317611.1 E3 ubiquitin-protein ligase TTC3 isoform 4
NM_001330683.2 NP_001317612.1 E3 ubiquitin-protein ligase TTC3 isoform 1
NM_001353936.2 NP_001340865.1 E3 ubiquitin-protein ligase TTC3 isoform 4
NM_001353937.2 NP_001340866.1 E3 ubiquitin-protein ligase TTC3 isoform 5
NM_001353938.2 NP_001340867.1 E3 ubiquitin-protein ligase TTC3 isoform 5
NM_003316.4 NP_003307.3 E3 ubiquitin-protein ligase TTC3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
20059950 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20059950 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20059950 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20059950 GOA
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
20059950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTC3 Protein Structure

TPR_11

TPR_11: TPR repeat (233 - 291)

TPR_1

TPR_1: Tetratricopeptide repeat (578 - 603)

zf-RING_2

zf-RING_2: Ring finger domain (1956 - 1996)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2025 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TTC3

  • RING finger protein 105

TTC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TTC3 P53804 AKT2 Homo sapiens P31751
Y2H
20059950
Intra
TTC3 P53804 AKT2 Homo sapiens P31751
Anti Tag CoIP
20059950
Intra
TTC3 P53804 AKT3 Homo sapiens Q9Y243
Anti Tag CoIP
20059950
Intra
TTC3 P53804 SMURF2 Homo sapiens Q9HAU4
Anti Tag CoIP
30696809
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Intellectual Developmental Disorder, Autosomal Dominant 7

  • MRD7

  • Mental Retardation, Autosomal Dominant 7

  • Autosomal Dominant Non-Syndromic Intellectual Disability 7

  • Dyrk1a Syndrome

  • Autosomal Dominant Intellectual Developmental Disorder 7

  • Autosomal Dominant Mental Retardation 7

  • Mental Retardation, Autosomal Dominant, Type 7
Cataract 4, Multiple Types

  • Cataract 4 Multiple Types

  • CTRCT4

  • Cca3

  • Pcc

  • Aculeiform Cataract

  • Cataract 4, Multiple Types, With Or Without Microcornea

  • Cataract, Crystalline Aculeiform

  • Caca

  • Cataract, Congenital, Cerulean Type, 3

  • Congenital Cataract Cerulean Type 3

  • Cataract Congenital Dominant Non Nuclear

  • Ccp

  • Cataract, Nonnuclear Polymorphic Congenital

  • Cataract, Punctate, Progressive Juvenile-Onset

  • Cataract 4 Multiple Types With Or Without Microcornea

  • Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

  • Cataract, Polymorphic Congenital

  • Congenital Cataract Blue Dot Type 3

  • Congenital Non-Nuclear Polymorphic Cataract

  • Crystalline Aculeiform Cataract

  • Punctate, Progressive Juvenile-Onset, Cataract

  • Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Chromosomal Duplication Syndrome
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS15208 TTC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TTC3 VGNC VGNC:36469
Canis familiaris TTC3 VGNC VGNC:47950
Mus musculus TTC3 MGD MGI:1276539
Rattus norvegicus TTC3 RGD RGD:1308654
Macaca mulatta TTC3 VGNC VGNC:81785
Others TTC3 NCBI