Dab2 - DAB adaptor protein 2 Gene

Also Known as Doc2; Doc-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79128

Summary

Enables low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to growth factor stimulus; negative regulation of signal transduction; and positive regulation of transport. Located in clathrin-coated vesicle membrane; perinuclear region of cytoplasm; and plasma membrane. Used to study myocardial infarction. Biomarker of metabolic acidosis and myocardial infarction. Orthologous to human DAB2 (DAB adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Dab2 Products (1)

mRNA Protein Name
NM_024159.2 NP_077073.1 disabled homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables low-density lipoprotein particle receptor binding IPI
IPI: Inferred from physical interaction
16306401 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10769163 RGD
Biological Process GO Annotation Evidence Références Source
involved in cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
12473651 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
21762377 RGD
involved in clathrin coat assembly IMP
IMP: Inferred from mutant phenotype
19000037 RGD
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
12473651 RGD
involved in negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
21762377 RGD
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
11371563 RGD
involved in negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
9681506 RGD
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
17317100 RGD
involved in positive regulation of aldosterone biosynthetic process IDA
IDA: Inferred from direct assay
17303656 RGD
involved in positive regulation of aldosterone secretion IDA
IDA: Inferred from direct assay
17303656 RGD
involved in positive regulation of endocytosis IDA
IDA: Inferred from direct assay
19000037 RGD
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
19000037 RGD
involved in regulation of Rho-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9681506 RGD
involved in response to salt IEP
IEP: Inferred from expression pattern
17303656 RGD
involved in response to steroid hormone IMP
IMP: Inferred from mutant phenotype
9681506 RGD
Cellular Component GO Annotation Evidence Références Source
located in clathrin-coated vesicle membrane IDA
IDA: Inferred from direct assay
19000037 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21080337 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disabled homolog 2

  • C9

  • DAB2, clathrin adaptor protein

  • adaptor molecule disabled-2

  • differentially expressed in ovarian carcinoma 2

  • disabled 2, mitogen-responsive phosphoprotein

  • disabled homolog 2 mitogen-responsive phosphoprotein

  • mitogen-responsive phosphoprotein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03511 DAB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112114 DTPA-DAB2 / Unkown
HY-RS03512 DAB2IP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20265 Dab2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26773 Dab2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dab2 NCBI NCBI:1601