Germacrene B
Based on 1 Customer Validation
Germacrene B is a central intermediate in sesquiterpene biosynthesis. Germacrene B has been ascribed a warm, sweet, woody-spicy, geranium-like odour and is an important flavour constituent of lime peel oil. Germacrene B is also one of the main constituents of the essential oils from different plants that have antibacterial activity.
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- Pureté : 99.93%
- CAS No.: 15423-57-1
- Formule: C15H24
- Masse moléculaire:204.35
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Stockage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
6.4 μg/mL
Compound: (E,E)-germacr-1(10),4,7(11)-triene
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Cytotoxicity against human A2780 cells
Cytotoxicity against human A2780 cells
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[PMID: 15165160] |
Chemical Information
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CAS No. 15423-57-1
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Appearance Oil
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Masse moléculaire 204.35
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Formule C15H24
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Color Colorless to light yellow
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SMILES
C/C(C)=C1C/C=C(C)/CC/C=C(C)/CC\1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Protocole
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Bacterial live/dead nucleic-acid viability staining
The LIVE/DEAD bacterial viability staining method is based on differential permeability of nucleic-acid-binding fluorescent dyes, most commonly SYTO 9 and propidium iodide (PI), which enables discrimination of bacterial populations with intact versus compromised cytoplasmic membranes. SYTO 9 penetrates both intact and damaged bacterial membranes and binds nucleic acids to produce green fluorescence, whereas propidium iodide penetrates only cells with compromised membranes and fluoresces red while also reducing SYTO 9 signal through competitive binding and fluorescence interactions. The resulting fluorescence pattern is interpreted as a proxy for membrane integrity, which is widely used as an indicator of bacterial viability in microscopy, flow cytometry, and spectroscopic platforms. However, mechanistic studies show that SYTO 9 and PI interactions involve displacement and fluorescence resonance energy transfer effects, which can influence signal interpretation depending on dye ratios a
Pureté et documentation
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Fiche technique (272 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Xu H, Dickschat JS. Germacrene B - a central intermediate in sesquiterpene biosynthesis. Beilstein J Org Chem. 2023 Feb 20;19:186-203. [Content Brief]
[2]. Figueiredo PLB, Pinto LC, da Costa JS, da Silva ARC, Mourão RHV, Montenegro RC, da Silva JKR, Maia JGS. Composition, antioxidant capacity and cytotoxic activity of Eugenia uniflora L. chemotype-oils from the Amazon. J Ethnopharmacol. 2019 Mar 25;232:30-38. [Content Brief]
[3]. Pereira TS, Machado Esquissato GN, Costa EV, Nogueira PCL, Castro-Prado MAA. Mutagenic and cytostatic activities of the Xylopia laevigata essential oil in human lymphocytes. Nat Prod Res. 2021 May;35(10):1682-1685. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Germacrene B Related Classifications
HY-135873 Related Classifications
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