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Cat. No.: HY-177020

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GS-6620 PM

Name: GS-6620 PM
Brand: MedChemExpress
SKU: HY-177020
Availability: PreOrder

(Synonyms: 1'-Cyano-2'-C-methyl 4-aza-7,9-dideaza adenosine)

GS-6620 PM (Compound 2) is an analog of 2′-C-methyl 4-aza-7,9-dideaza adenosine. 2′-C-methyl 4-aza-7,9-dideaza adenosine is an inhibitor of HCV replication in cell culture. GS-6620 PM can be used in the study of hepatitis C virus (HCV) infection.

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CAS No.: 1191237-49-6
Formule: C₁₃H₁₅N₅O₄
Masse moléculaire:305.29

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

GS-6620 PM Chemical Structure

CAS No.: 1191237-49-6

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	50 μM Compound: 13	Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay	[PMID: 28124907]
HEp-2	CC₅₀	>100 μM Compound: 10	Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 4 to 5 days by CellTiter Glo viability assay Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 4 to 5 days by CellTiter Glo viability assay	[PMID: 33835812]
HEp-2	CC₅₀	>100 μM Compound: 13	Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay	[PMID: 28124907]
HEp-2	EC₅₀	>100 μM Compound: 10	Antiviral activity against RSV A2 infected in HEp-2 cells assessed as reduction in virus-induced cytopathic effect after 4 days by CellTiter Glo viability assay Antiviral activity against RSV A2 infected in HEp-2 cells assessed as reduction in virus-induced cytopathic effect after 4 days by CellTiter Glo viability assay	[PMID: 33835812]
Huh-7	CC₅₀	>44 μM Compound: 13	Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 3 days by calcein-AM dye based fluorescence assay Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 3 days by calcein-AM dye based fluorescence assay	[PMID: 28124907]
Huh-7	CC₅₀	>89 μM Compound: 10	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 3 days by dual-Glo luciferase assay Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 3 days by dual-Glo luciferase assay	[PMID: 33835812]
Huh-7	EC₅₀	>89 μM Compound: 2	Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luminescence assay Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luminescence assay	[PMID: 23547794]
MT4	CC₅₀	>200 μM Compound: 10	Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by CellTiter Glo viability assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by CellTiter Glo viability assay	[PMID: 33835812]
MT4	CC₅₀	>57 μM Compound: 13	Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay	[PMID: 28124907]

Chemical Information

CAS No. 1191237-49-6
Masse moléculaire 305.29
Formule C₁₃H₁₅N₅O₄
SMILES

NC1=NC=NN2C1=CC=C2[C@@]3(C#N)[C@@](O)(C)[C@H](O)[C@@H](CO)O3
Synonyms

1'-Cyano-2'-C-methyl 4-aza-7,9-dideaza adenosine
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cho A, et al. Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients. J Med Chem. 2014 Mar 13;57(5):1812-25. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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