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Cat. No.: HY-103063

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Iso-PU-H54

Iso-PU-H54 is a purine-scaffold Grp94 inhibitor with an IC₅₀ of 1.63 μM.

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CAS No.: 852030-37-6
Formule: C₁₈H₁₉N₅S
Masse moléculaire:337.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Iso-PU-H54 Chemical Structure

CAS No.: 852030-37-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Iso-PU-H54 is a purine-scaffold Grp94 inhibitor with an IC₅₀ of 1.63 μM^[1].

Voir tous les produits spécifiques à Isoform HSP :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-BR-3	IC₅₀	31.8 μM Compound: 11k	Inhibitory concentration against SKBr3 cell line Inhibitory concentration against SKBr3 cell line	[PMID: 15828828]

In Vitro

Iso-PU-H54 (compound 9i) inhibits recombinant Trap-1 with an IC₅₀ of 13.8 μM and shows no significant activity against recombinant Hsp90α or Hsp90β (IC₅₀ > 300 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 852030-37-6
Masse moléculaire 337.45
Formule C₁₈H₁₉N₅S
SMILES

C#CCCCN1C(=NC=2C(=NC=NC21)N)SC3=CC=C(C=C3C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Patel HJ, et al. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem. 2015;58(9):3922-3943. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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