Kojic acid (Standard)
Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields.
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- CAS No.: 501-30-4
- Formule: C₆H₆O₄
- Masse moléculaire:142.11
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 501-30-4
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Masse moléculaire 142.11
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Formule C₆H₆O₄
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SMILES
O=C1C=C(CO)OC=C1O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Wei X, et al. Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways. Exp Eye Res. 2018 Dec 28;180:174-183. [Content Brief]
[2]. Burnett C L, et al. Final report of the safety assessment of kojic acid as used in cosmetics[J]. International journal of toxicology, 2010, 29(6_suppl): 244S-273S. [Content Brief]
[3]. Saeedi M, et al. Kojic acid applications in cosmetic and pharmaceutical preparations. Biomed Pharmacother. 2019 Feb;110:582-593. doi: 10.1016/j.biopha.2018.12.006. [Content Brief]
[4]. Kim T Y, et al. Nematicidal activity of kojic acid produced by Aspergillus oryzae against Meloidogyne incognita[J]. Journal of Microbiology and Biotechnology, 2016, 26(8): 1383-1391. [Content Brief]
[5]. Zilles J C, et al. Biological activities and safety data of kojic acid and its derivatives: A review[J]. Experimental dermatology, 2022, 31(10): 1500-1521. [Content Brief]
[7]. Karakaya G, et al. Synthesis and cytotoxic evaluation of kojic acid derivatives with inhibitory activity on melanogenesis in human melanoma cells[J]. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 2018, 18(15): 2137-2148. [Content Brief]
[8]. Khan A, et al. Antioxidative and Anti-inflammatory Effects of Kojic Acid in Aβ-Induced Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2021 Oct;58(10):5127-5140. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kojic acid (Standard) Related Classifications
HY-W050154R Related Classifications
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- Kojic acid (Standard)
- 501-30-4
- Reference Standards
- Parasite
- Tyrosinase
- NF-κB
- CDK
- HCEC-B4G12?cells
- B16-4A5 cells
- HMV-II cells
- β-Amyloid (1-42)
- human (HY-P1363A)-Induced Mouse Model of Alzheimer's Disease
- Anti-aging activity
- Anti-cancer activity
- Anti-nematode activity
- Antimicrobial activity
- Antioxidant activity
- and Anti-inflammatory activity,
- Inhibitor
- inhibitor
- inhibit