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Cat. No.: HY-118293

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L 708286

Name: L 708286
Brand: MedChemExpress
SKU: HY-118293
Availability: PreOrder

(Synonyms: DFKi)

L 708286 (DFKi) is a slow-binding inhibitor of human leukocyte elastase (HLE). L 708286 is a peptide-based phenethylcarbamoyl difluoromethylene compound. L 708286 can be used in the study of respiratory diseases.

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CAS No.: 119720-81-9
Formule: C₂₅H₃₄F₂N₄O₅
Masse moléculaire:508.56

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

L 708286 Chemical Structure

CAS No.: 119720-81-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
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Activité biologique

Description

In Vitro

L 708286 (DFKi) shows a high degree of three-dimensional structural consistency with the TOMI fragment (Ala-15-Tyr-20) (based on molecular shape matching analysis of crystallographic data), with a maximum spatial overlap volume of 65.4 to 95.4 Å^3[1].
L 708286 shows a high degree of conformational agreement with the full-length TOMI protein, as determined by molecular shape matching analysis based on crystallographic data. Under different atomic radius parameters (SA-UA and vdW-UA), the maximum spatial overlap volumes between the two are 86.4 Å³ and 325.5 Å³, respectively^[1].
L 708286 shows a high degree of spatial conformational agreement with the full-length relaxed TOMI protein (as determined by three-dimensional molecular shape matching analysis based on crystallographic data), representing one of the highest-scoring hits, with a spatial overlap volume of 63.4 Å³ under the SA-UA parameter^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 119720-81-9
Masse moléculaire 508.56
Formule C₂₅H₃₄F₂N₄O₅
SMILES

O=C([C@H]1N(CCC1)C([C@@H](NC(C)=O)C)=O)N[C@H](C(C(F)(C(NCCC2=CC=CC=C2)=O)F)=O)C(C)C
Synonyms

DFKi
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Masek BB, et al. Molecular skins: a new concept for quantitative shape matching of a protein with its small molecule mimics. Proteins. 1993 Oct;17(2):193-202.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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