Losartan azide
Losartan azide is a click chemistry reagent containing an azide group and is a synthetic intermediate for the preparation of angiotensin AT1R-targeted renal PET imaging probe [18 F]fluoropyridine-losartan.
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- CAS No.: 727718-93-6
- Formule: C22H22ClN9
- Masse moléculaire:447.92
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Description
Chemical Information
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CAS No. 727718-93-6
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Masse moléculaire 447.92
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Formule C22H22ClN9
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SMILES
ClC1=C(N(CC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=NN4)C(CCCC)=N1)CN=[N+]=[N-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Losartan azide Related Classifications
HY-W724743 Related Classifications
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