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Cat. No.: HY-167898

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MeS-IMPY

MeS-IMPY is a ligand of β-amyloid plaques. MeS-IMPY shows a high binding affinity to β-amyloid plaques extracted from Alzheimer's disease (AD) human brains or AD brain homogenates compared to IMPY (K_i=7.93 and 8.95 nM, respectively). [¹¹C]MeS-IMPY is a potential radioligand for imaging β-amyloid plaques with positron emission tomography (PET).

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CAS No.: 955376-42-8
Formule: C₁₆H₁₇N₃S
Masse moléculaire:283.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

MeS-IMPY Chemical Structure

CAS No.: 955376-42-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

CAS No. 955376-42-8
Masse moléculaire 283.39
Formule C₁₆H₁₇N₃S
SMILES

CSC1=CN2C=C(C3=CC=C(N(C)C)C=C3)N=C2C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Seneca N, et al. Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques. Nucl Med Biol. 2007 Aug;34(6):681-9. [Content Brief]

[2]. Seneca N, et al. Low retention of [S-methyl-11C] MeS-IMPY to β-amyloid plaques in patients with Alzheimer's disease[J]. Current Radiopharmaceuticals, 2009, 2(2): 129-136.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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