NJK14047
NJK14047 inhibits p38 MAPK and the differentation of naive T-cells to Th1 and Th17 cells. NJK14047 ameliorates the collage-induced rheumatoid arthritis and Imiquimod (HY-B0180)-induced psoriasis in mice.
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- CAS No.: 1800576-41-3
- Formule: C27H27NO5
- Masse moléculaire:445.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
NJK14047 (3-10 μM) inhibits expressions of inflammatory cytokines IL-1β, TNF-α, IL-6, IL-17A, RANKL, and MMP-3 in Lipopolysaccharid (HY-D1056) stimulated human SW982 synovial cells[1].
NJK14047 (3-10 μM) inhibits the differentation of naive CD4+T cells into Th1, Th2 and Th17 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:collage-induced rehumatoid arthritis in DBA-1J mice and imiquimod-induced psoriasis in BALB/c mice[1]
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Dosage:2.5 mg/kg
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Administration:i.p. for 7 days for IIP-administrated BALB/c mice, i.p. for 21 days for CIA-administrated CBA-1J mice
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Result:Ameliorated the collage-induced arthritis and CIA caused cartilage damage, inflammation, pannus formation, bone corrosion, and synovial hyperplasia.
Ameliorated the imiquimod induced psoriasis and IIP caused keratinocyte proliferation.
Chemical Information
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CAS No. 1800576-41-3
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Masse moléculaire 445.51
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Formule C27H27NO5
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SMILES
O=C(C1=CC(C2=CC=C(C(C3=CC=C(OCC(O)CO)C=C3)=O)C=C2)=C(C)C=C1)NC4CC4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NJK14047 Related Classifications
HY-120225 Related Classifications
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