NMT-IN-8
NMT-IN-8 (Compound Ex.129) is an orally active and highly selective inhibitor of N-myristoyl transferase (NMT) with an IC50 value of ＜10 nM. NMT-IN-8 binds to the peptide binding pocket of NMT, blocking its catalyzed protein N-myristoylation to interfere with key pathways such as protein trafficking, signal transduction, and viral replication. NMT-IN-8 is promising for research of oncology (e.g., MYC-addicted cancers, B-cell lymphoma) and infectious diseases (e.g., malaria, HIV, rhinovirus infection).
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- CAS No.: 2765258-26-0
- Formule: C23H29ClN8O
- Masse moléculaire:468.98
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Chemical Information
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CAS No. 2765258-26-0
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Masse moléculaire 468.98
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Formule C23H29ClN8O
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SMILES
O=C(C1CN(C2=NC(N3[C@H](CNCC3)C)=NC=C2Cl)C1)NC(C)(C4=CN=C5N4C=CC=C5)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NMT-IN-8 Related Classifications
HY-171788 Related Classifications
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