2765258-26-0
Chemical Structure
NMT-IN-8
- CAS No.: 2765258-26-0
- Formula:C23H29ClN8O
- Molecular Weight:468.98
SMILES: O=C(C1CN(C2=NC(N3[C@H](CNCC3)C)=NC=C2Cl)C1)NC(C)(C4=CN=C5N4C=CC=C5)C
Biological Activity: NMT-IN-8 (Compound Ex.129) is an orally active and highly selective inhibitor of N-myristoyl transferase (NMT) with an IC50 value of ＜10 nM. NMT-IN-8 binds to the peptide binding pocket of NMT, blocking its catalyzed protein N-myristoylation to interfere with key pathways such as protein trafficking, signal transduction, and viral replication. NMT-IN-8 is promising for research of oncology (e.g., MYC-addicted cancers, B-cell lymphoma) and infectious diseases (e.g., malaria, HIV, rhinovirus infection)[1].
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NMT-IN-8 | NMT-IN-8 (Compound Ex.129) is an orally active and highly selective inhibitor of N-myristoyl transferase (NMT) with an IC50 value of ＜10 nM. NMT-IN-8 binds to the peptide binding pocket of NMT, blocking its catalyzed protein N-myristoylation to interfere with key pathways such as protein trafficking, signal transduction, and viral replication. NMT-IN-8 is promising for research of oncology (e.g., MYC-addicted cancers, B-cell lymphoma) and infectious diseases (e.g., malaria, HIV, rhinovirus infection). | |||||||||||||||||||||
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Keywords
