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Cat. No.: HY-181853

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NOTA-SP2A-PSMAL

NOTA-SP₂A-PSMAL is a ligand targeting prostate-specific membrane antigen (PSMA), which competitively binds to PSMA with high binding affinity and an IC₅₀ value of 0.26 nM. ¹⁸F-labeled NOTA-SP₂A-PSMAL can be used as a PET tracer for positron emission tomography imaging of prostate cancer. NOTA-SP₂A-PSMAL can be used for the synthesis and research of radionuclide conjugates (RDCs).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₅₅H₇₉N₁₁O₂₅S₂
Masse moléculaire:1358.40

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NOTA-SP2A-PSMAL Chemical Structure

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One-Stop Platform：From Independent R&D to Pilot-Scale Production

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Radionuclide-Drug Conjugates (RDCs) :

In Vitro

NOTA-SP₂A-PSMAL exhibits a binding energy of -10.2 K_cal/mol and forms equivalent hydrogen bonds with human PSMA protein compared to NOTA-PSMA-BCH, indicating comparable binding stability^[1].
NOTA-SP₂A-PSMAL (10^-12 to 10^-5 M; 60 min) competitively binds to PSMA in 22Rv1 cells with high binding affinity (IC₅₀ = 0.26 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 1358.40
Formule C₅₅H₇₉N₁₁O₂₅S₂
SMILES

OC(CC[C@H](C(O)=O)NC(NC(C(O)=O)CCCCNC(C(CC1=CC=C(C=CC=C2)C2=C1)NC([C@H]3CC[C@@H](CNC([C@@H](CC(O)=O)NC([C@H](CS(=O)(O)=O)NC([C@@H](CS(=O)(O)=O)NC(CN4CCN(CC(O)=O)CCN(CC(O)=O)CC4)=O)=O)=O)=O)CC3)=O)=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhang Y, et al. Design, Synthesis, and Preclinical Evaluation of a Novel [¹⁸F]AlF-Labeling Positron Emission Tomography Tracer Targeting Prostate-Specific Membrane Antigen. J Med Chem. 2026;69(4):4888-4899. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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