PEG-DPCA conjugate 1
PEG-DPCA conjugate 1 is a PEG-DPCA conjugate that can co-assemble with mPEG-Amide-tri(DPCA) (HY-179320) into a supramolecular polymer hydrogel with nanofiber structures. The supramolecular polymer hydrogel exhibits shear-thinning behavior for injectable delivery, high drug loading, and degrades in vivo to release only DPCA and PEG, induces in vivo earhole regeneration in adult non-healing mice. PEG-DPCA conjugate 1 can be used for tissue regeneration research.
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- CAS No.: 2459303-78-5
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Activité biologique
Description
Chemical Information
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CAS No. 2459303-78-5
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SMILES
O=C(NC(COC(C1=CNC2=C(C1=O)C=CC3=CC=CN=C32)=O)(COC(C4=CNC5=C(C4=O)C=CC6=CC=CN=C65)=O)COC(C7=CNC8=C(C7=O)C=CC9=CC=CN=C98)=O)COCCOCC(NC(COC(C%10=CNC%11=C(C%10=O)C=CC%12=CC=CN=C%12%11)=O)(COC(C%13=CNC%14=C(C%13=O)C=CC%15=CC=CN=C%15%14)=O)COC(C(C%16=O)=CNC%17=C%16C=CC%18=CC=CN=C%17%18)=O)=O.[n]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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3D Hydrogel Synthetic Scaffold Culture
3D hydrogel synthetic scaffold culture embeds cells, spheroids, organoids, or tissue fragments inside a hydrated crosslinked polymer network so that cells receive matrix and cell-cell cues in three dimensions rather than from a flat plastic surface. A literature-supported model protocol is PEG-4MAL hydrogel culture, in which four-arm maleimide-terminated PEG is functionalized with cysteine-containing adhesive peptides such as RGD and crosslinked with protease-degradable peptides such as GPQ-W; this creates a defined, modular scaffold that supports human organoid generation and culture. The readouts are scaffold-supported growth, morphology, lumen formation, budding, viability, proliferation, lineage-marker expression, and matrix-dependent expansion or differentiation; reported assays include transmitted-light imaging, immunofluorescence, in situ hybridization, qRT-PCR, and rheological characterization.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PEG-DPCA conjugate 1 Related Classifications
HY-179313 Related Classifications
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