CD301/CLEC10A
CD301, also known as macrophage galactose-type C-type lectin (MGL, gene CLEC10A), is a type II transmembrane lectin receptor expressed on immature dendritic cells and macrophages. Its single extracellular carbohydrate-recognition domain binds terminal galactose and N-acetylgalactosamine residues in a calcium-dependent manner, including the tumor-associated T and Tn glycans. Through this specificity, CD301 mediates uptake of glycosylated antigens and shapes glycan-dependent immune responses. Expression is characteristic of alternatively activated, M2-like macrophages, and the receptor has been exploited for targeted delivery to macrophages and dendritic cells in tumor and autoimmune models. Internalized ligands are routed to antigen-processing compartments, supporting CD301's role in glycoprotein antigen presentation.
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CD301/CLEC10A Protéines Recombinantes (1)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
