Trbl
The Trbl group comprises the mammalian Tribbles proteins TRIB1, TRIB2, and TRIB3, pseudokinases that lack catalytic activity but serve as dynamic scaffolds. A degraded kinase domain is flanked by a MEK1-binding region and a C-terminal COP1-binding motif that recruits the E3 ubiquitin ligase to substrates. TRIB1 controls lipid metabolism and macrophage differentiation by promoting C/EBP alpha degradation, and common variants near TRIB1 raise plasma triglycerides and coronary artery disease risk. TRIB2 cooperates in acute myeloid leukemia and lung tumorigenesis, while endoplasmic reticulum stress-inducible TRIB3 modulates AKT signaling, insulin action, and glucose production, linking this family to cardiometabolic disease and cancer.
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Trbl Protéines Recombinantes (2)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
