TRIB1/Trb1
Among the three mammalian tribbles proteins, TRIB2 (Trb-2) stands out as a potent oncoprotein in hematopoietic malignancies. Like its siblings TRIB1 and TRIB3, it is a catalytically inactive pseudokinase that couples the COP1 ubiquitin ligase to substrates through a C-terminal degron, promoting degradation of the myeloid master regulator C/EBPα and of acetyl-CoA carboxylase. Overexpressed in a subset of acute myeloid leukemia, TRIB2 blocks differentiation and confers resistance to chemotherapy while engaging AKT signaling. Expression is enriched in proliferating cells and in ovarian and other solid tumors, and its disruption of C/EBPα homeostasis provides a mechanistic link between pseudokinase adaptors and leukemogenesis.
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TRIB1/Trb1 Recombinant Proteins (1)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
