Secoiridoid analogues from the fruits of Ligustrum lucidum and their inhibitory activities against influenza A virus

  • Bioorg Med Chem Lett. 2018 May 15;28(9):1516-1519. doi: 10.1016/j.bmcl.2018.03.080.
Xu Pang  1 ,  Jian-Yuan Zhao  2 ,  Hai-Yang Yu  1 ,  Li-Yan Yu  2 ,  Tao Wang  1 ,  Yi Zhang  1 ,  Xiu-Mei Gao  3 ,  Li-Feng Han  4
Affiliations
  • 1. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
  • 2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • 3. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
  • 4. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: [email protected].
PMID: 29625823 DOI: 10.1016/j.bmcl.2018.03.080
Abstract

A phytochemical study focusing on the secoiridoid components in the fruits of Ligustrum lucidum was carried out, which finally led to the isolation of nine secoiridoid glycosides (1-9) together with two secoiridoids (10, 11). The structures of all compounds were established mainly by NMR and MS experiments as well as the necessary chemical evidence, of which 1, 2, 4 (ligulucisides A-C), 10 and 11 (liguluciridoids A and B) were identified as new secoiridoid analogues. An in vitro Antiviral bioassay indicated that 1, 4, 6, and 10 displayed the inhibitory activities against influenza A virus with the IC50 values of 16.5, 12.5, 13.1, and 18.5 μM, respectively, which were better than the positive control Ribavirin (IC50 22.6 μM). .

Keywords
Influenza A virus; Ligustrum lucidum; Oleaceae; Secoiridoid.
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