Rhein Prevents APAP-induced drug-induced Liver Injury by Upregulating Nrf2 and Inhibiting APAP-activating Enzymes

  • Cell Biochem Biophys. 2026 Jan 18. doi: 10.1007/s12013-026-02005-3.
Mingda Liu  1 ,  Jin Dai  2 ,  Liangding Dou  1 ,  Zifeng Deng  1  3 ,  Junxian Liu  1 ,  Xin Hou  1 ,  Jinwen Zhang  1  4 ,  YongChao Huang  1 ,  Zhi Huang  1 ,  Dai Wang  1 ,  Dongbei Guo  1 ,  Ran An  1 ,  Youliang Yao  1 ,  Yongxing Zhang  5
Affiliations
  • 1. State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, xiamen City, Fujian province, China.
  • 2. Jinshan College, Fujian Agriculture and Forestry University, Fujian Province, Fuzhou City, 350000, China.
  • 3. School of Public Health, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, 999077, PR China.
  • 4. Zherong County Center for Disease, Control and Prevention, Ningde City, Fujian Province, 352000, China.
  • 5. State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, xiamen City, Fujian province, China. [email protected].
PMID: 41548181 DOI: 10.1007/s12013-026-02005-3
Keywords
APAP; APAP-activating enzymes; Drug-induced liver injury; Nrf2; RA.
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