Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia

  • J Nat Prod. 1997 Jun;60(6):606-8. doi: 10.1021/np970163+.
T S Wu  1 ,  M J Liou ,  C S Kuoh ,  C M Teng ,  T Nagao ,  K H Lee
Affiliations
  • 1. Department of Chemistry, National Cheng-Kung University, Tainan, Taiwan, Republic of China.
PMID: 9214732 DOI: 10.1021/np970163+
Abstract

Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six Cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively.