RFI-641
RFI-641 is a selective inhibitor of the respiratory syncytial virus (RSV), with an IC50 of 50 nM. RFI-641 inhibit binding and fusion of enveloped virus via interaction with the viral fusion protein.
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- CAS No.: 197366-24-8
- Formule: C58H60N24Na2O22S6
- Masse moléculaire:1683.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HFF | IC50 |
0.05 μM
Compound: 3 (RF-1461)
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Inhibitory concentration against human respiratory syncytial virus strain A2 in human foreskin fibroblasts
Inhibitory concentration against human respiratory syncytial virus strain A2 in human foreskin fibroblasts
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[PMID: 15603966] |
| HFF | IC50 |
2.55 μM
Compound: 3 (RF-1461)
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Inhibitory concentration against human cytomegalovirus strain Ad169 in human foreskin fibroblasts
Inhibitory concentration against human cytomegalovirus strain Ad169 in human foreskin fibroblasts
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[PMID: 15603966] |
| Vero | IC50 |
7.72 μM
Compound: 3 (RF-1461)
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Inhibitory concentration against herpes simplex 1 strain Patton in vero cells
Inhibitory concentration against herpes simplex 1 strain Patton in vero cells
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[PMID: 15603966] |
Chemical Information
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CAS No. 197366-24-8
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Masse moléculaire 1683.61
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Formule C58H60N24Na2O22S6
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SMILES
O=C(CN(S(=O)(C1=CC(NC2=NC(NC3=CC(S(=O)(O[Na])=O)=C(C4=CC=C(NC5=NC(NC6=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C6)=NC(NC7=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C7)=N5)C=C4S(=O)(O[Na])=O)C=C3)=NC(NC8=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C8)=N2)=CC=C1)=O)CC(N)=O)N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
[1]. Nikitenko AA, et, al. The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1041-4. [Content Brief]
[2]. Razinkov V, et, al. RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein. Chem Biol. 2001 Jul;8(7):645-59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RFI-641 Related Classifications
HY-19874 Related Classifications
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