Pyrimidine containing RSV fusion inhibitors

  • Bioorg Med Chem Lett. 2005 Jan 17;15(2):427-30. doi: 10.1016/j.bmcl.2004.10.056.
Antonia Nikitenko  1 ,  Yuri Raifeld ,  Boris Mitsner ,  Howard Newman
Affiliations
  • 1. Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA. [email protected]
PMID: 15603966 DOI: 10.1016/j.bmcl.2004.10.056
Abstract

The knowledge of SAR in a series of biphenyl anionic RSV inhibitors has been broadened by synthesis and testing of analogs with pyrimidine linkers. Generally, pyrimidine compounds were much harder to synthesize, and their anti-RSV activity was lower in comparison with triazine analogs.