The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus
- Bioorg Med Chem Lett. 2001 Apr 23;11(8):1041-4. doi: 10.1016/s0960-894x(01)00150-0.
Affiliations
- 1. Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA. [email protected]
PMID: 11327584
DOI: 10.1016/s0960-894x(01)00150-0
Abstract
The design and synthesis of a new potent and selective inhibitor of the respiratory syncytial virus are described. This compound, RFI-641, emerged from analysis of the structure-activity relationship in a series of biphenyl triazine anionic compounds possessing specific anti-RSV activity. The key synthetic step involves coupling of diaminobiphenyl 11 with two equivalents of chlorotriazine 10 under microwave conditions. RFI-641 inhibited RSV in vitro and in vivo models.