TQ05310
TQ05310 is an orally available inhibitor of IDH2 mutants, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutants. TQ05310 inhibits the production of 2-hydroxyglutarate (2-HG) and induces differentiation of cells expressing IDH2-R140Q and IDH2-R172K by inhibiting the enzymatic activity of mutant IDH2. TQ05310 can be used for the study of acute myeloid leukemia.
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- CAS No.: 2071196-10-4
- Formule: C19H17F6N7O
- Masse moléculaire:473.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
IDH2-R140Q 136.9 nM (IC50) |
IDH2‐R172K 37.9 nM (IC50) |
Chemical Information
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CAS No. 2071196-10-4
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Masse moléculaire 473.37
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Formule C19H17F6N7O
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SMILES
FC(F)(F)C1=CC=CC(C2=NC(NC3=CC=NC(C(F)(F)F)=C3)=NC(NOC(C)(C)C)=N2)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TQ05310 Related Classifications
HY-164542 Related Classifications
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