ULK1-IN-5
ULK1-IN-5 (Compound D1) is a selective ULK1 inhibitor with an IC50 of 14.91 nM. ULK1-IN-5 functionally inhibits the kinase activity of ULK1. ULK1-IN-5 reduces the phosphorylation level of ATG13. ULK1-IN-5 exerts antiproliferative effects on cervical cancer cells. ULK1-IN-5 is applicable to relevant research on cervical cancer.
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- Formule: C31H42F3N7O3
- Masse moléculaire:617.71
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
ULK1 14.91 nM (IC50) |
In Vitro
ULK1-IN-5 (starting concentration 100 μM, with serial dilution; enzyme incubation for 10 min) potently inhibits purified ULK1 enzyme, with an IC50 of 14.91 ± 1.06 nM[1].
ULK1-IN-5 inhibits the proliferation of HeLa cells with an IC50 of 0.83 μM, and reduces the level of ULK1-mediated ATG13 phosphorylation in these cells[1].
ULK1-IN-5 (compound D1) (range of concentrations) exhibits low cytotoxicity against normal HUVEC cells, with an IC50 of 11.93 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 617.71
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Formule C31H42F3N7O3
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SMILES
O=C(OC(C)(C)C)N1CCN(C2=CC(C3CC3)=C(NC4=NC(NCCCN5C(CCCC5)=O)=C(C(F)(F)F)C=N4)C=C2)CC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ULK1-IN-5 Related Classifications
HY-181699 Related Classifications
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