UNC3474
Based on 1 Customer Validation
UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1TT, with a dissociation constant (Kd) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells.
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- Pureté: 98.56%
- CAS No.: 1648707-79-2
- Formule: C17H28N2O
- Masse moléculaire:276.42
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Unlike WT 53BP1TT, 53BP1TT-PN dose not interact with UNC3474[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1648707-79-2
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Appearance Oil
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Masse moléculaire 276.42
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Formule C17H28N2O
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=CC(C(C)C)=C1)NCCCNC(C)(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (361.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6177 mL | 18.0884 mL | 36.1768 mL | 90.4421 mL |
| 5 mM | 0.7235 mL | 3.6177 mL | 7.2354 mL | 18.0884 mL | |
| 10 mM | 0.3618 mL | 1.8088 mL | 3.6177 mL | 9.0442 mL | |
| 15 mM | 0.2412 mL | 1.2059 mL | 2.4118 mL | 6.0295 mL | |
| 20 mM | 0.1809 mL | 0.9044 mL | 1.8088 mL | 4.5221 mL | |
| 25 mM | 0.1447 mL | 0.7235 mL | 1.4471 mL | 3.6177 mL | |
| 30 mM | 0.1206 mL | 0.6029 mL | 1.2059 mL | 3.0147 mL | |
| 40 mM | 0.0904 mL | 0.4522 mL | 0.9044 mL | 2.2611 mL | |
| 50 mM | 0.0724 mL | 0.3618 mL | 0.7235 mL | 1.8088 mL | |
| 60 mM | 0.0603 mL | 0.3015 mL | 0.6029 mL | 1.5074 mL | |
| 80 mM | 0.0452 mL | 0.2261 mL | 0.4522 mL | 1.1305 mL | |
| 100 mM | 0.0362 mL | 0.1809 mL | 0.3618 mL | 0.9044 mL |
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