Carboxymethyl-β-cyclodextrin
Based on 1 Customer Validation
Carboxymethyl-β-cyclodextrin is a cationic cyclodextrin used as a carrier for drugs. It has been shown to bind nonsteroidal anti-inflammatory drugs (NSAIDs) with high affinity and selectivity.
For research use only. We do not sell to patients.
- Assay : 99.7%
- CAS No.: 218269-34-2
- Formula: C56H84O49
- Molecular Weight:1541.24
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
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Help & FAQs
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Biological Activity
Description
Chemical Information
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CAS No. 218269-34-2
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Appearance Solid
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Molecular Weight 1541.24
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Formula C56H84O49
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Color White to off-white
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SMILES
OC(CO[C@H]1[C@@]2([H])[C@H](O[C@@](O[C@@]3([H])[C@@H]([C@H]([C@](O[C@]4([H])[C@H](O[C@@](O[C@]5([H])[C@H](O[C@]([C@@H]([C@H]5O)O)([H])O[C@]6([H])[C@H](O[C@]([C@@H]([C@H]6O)O)([H])O[C@@]7([H])[C@@H]([C@H]([C@@](O[C@@H]7CO)([H])O[C@@]8([H])[C@@H]([C@H]([C@@](O[C@@H]8CO)([H])O2)O)OCC(O)=O)O)OCC(O)=O)COCC(O)=O)COCC(O)=O)([H])[C@@H]([C@H]4O)O)COCC(O)=O)([H])O[C@@H]3CO)O)OCC(O)=O)([H])[C@@H]1O)CO)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (64.88 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
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Data Sheet (260 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6488 mL | 3.2441 mL | 6.4883 mL | 16.2207 mL |
| 5 mM | 0.1298 mL | 0.6488 mL | 1.2977 mL | 3.2441 mL | |
| 10 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6221 mL | |
| 15 mM | 0.0433 mL | 0.2163 mL | 0.4326 mL | 1.0814 mL | |
| 20 mM | 0.0324 mL | 0.1622 mL | 0.3244 mL | 0.8110 mL | |
| 25 mM | 0.0260 mL | 0.1298 mL | 0.2595 mL | 0.6488 mL | |
| 30 mM | 0.0216 mL | 0.1081 mL | 0.2163 mL | 0.5407 mL | |
| 40 mM | 0.0162 mL | 0.0811 mL | 0.1622 mL | 0.4055 mL | |
| 50 mM | 0.0130 mL | 0.0649 mL | 0.1298 mL | 0.3244 mL | |
| 60 mM | 0.0108 mL | 0.0541 mL | 0.1081 mL | 0.2703 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Carboxymethyl-β-cyclodextrin Related Classifications
HY-126393 Related Classifications
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