1001405-52-2
Chemical Structure
PSMα3
- CAS No.: 1001405-52-2
- Formula:C128H192N28O30S
- Molecular Weight:2635.13
SMILES: [C@@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)CC(N)=O)=O)=O)CC(C)C)=O)=O)CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(O)=O)=O)CCCCN)=O)=O)(CC3=CC=CC=C3)NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC5=CC=CC=C5)NC([C@@H](NC([C@H](CCSC)NC=O)=O)CCC(O)=O)=O)=O)C(C)C)=O)C)=O)CCCCN)=O)CC(C)C)=O)=O)CCCCN)=O
Biological Activity: PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PSMα3 | 99.39% | PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Richardson JR, et al. Staphylococcus aureus PSM Peptides Modulate Human Monocyte-Derived Dendritic Cells to Prime Regulatory T Cells. Front Immunol. 2018 Nov 13;9:2603. [Content Brief]
- [2]. Kalitnik A, et al. Cytotoxic Staphylococcus aureus PSMα3 inhibits the aggregation of human insulin in vitro. Phys Chem Chem Phys. 2024 May 29;26(21):15587-15599. [Content Brief]
- [3]. Tayeb-Fligelman E, et al. The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril. Science. 2017 Feb 24;355(6327):831-833. [Content Brief]
Keywords
