1001468-07-0
Chemical Structure
BDM31343
- CAS No.: 1001468-07-0
- Formula:C14H14N4O2S
- Molecular Weight:302.35
InChIKey: SSTGJZVDCOEUFG-UHFFFAOYSA-N
SMILES: N#CCC(N1CCC(CC1)C2=NC(C3=CC=CS3)=NO2)=O
Biological Activity: BDM31343 is an Ethionamide (HY-B0276) synergist. BDM31343 inhibits the transcriptional repressor EthR in Mycobacterium tuberculosis, thereby relieving the inhibition of the EthA activator by Ethionamide, and enhancing the efficacy of Ethionamide. BDM31343 effectively inhibits the binding of EthR to DNA, with its IC₅₀ being 3.3 μM. BDM31343 can be used in the research of anti-Mycobacterium tuberculosis[1][2].
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BDM31343 | BDM31343 is an Ethionamide (HY-B0276) synergist. BDM31343 inhibits the transcriptional repressor EthR in Mycobacterium tuberculosis, thereby relieving the inhibition of the EthA activator by Ethionamide, and enhancing the efficacy of Ethionamide. BDM31343 effectively inhibits the binding of EthR to DNA, with its IC₅₀ being 3.3 μM. BDM31343 can be used in the research of anti-Mycobacterium tuberculosis. | |||||||||||||||||||||
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- [1]. Willand N, et al. Synthetic EthR inhibitors boost antituberculous activity of ethionamide. Nat Med. 2009 May;15(5):537-44. [Content Brief]
- [2]. Engohang-Ndong J. Antimycobacterial drugs currently in Phase II clinical trials and preclinical phase for tuberculosis treatment. Expert Opin Investig Drugs. 2012 Dec;21(12):1789-800. [Content Brief]
Keywords
