1007786-48-2
1007786-48-2
Chemical Structure
JNK-IN-23
- CAS No.: 1007786-48-2
- Formula:C19H18N4OS2
- Molecular Weight:382.50
InChIKey: ZYCFQLYFRCQEMK-UHFFFAOYSA-N
SMILES: CC(C1=NC(SC(C)=C2C)=C2C(N1)=O)SC3=NC4=C(N=C3C)C=CC=C4
Biological Activity: JNK-IN-23 (Compound K12) is an inhibitor of JNK. JNK-IN-23 inhibits the proliferation of MDA-MB-231 (GIC50: 30 nM). JNK-IN-23 blocks TNBC metastatic growth in vivo. JNK-IN-23 inhibits the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and pyruvate dehydrogenase complex (PDHC)[1].
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JNK-IN-23 | JNK-IN-23 (Compound K12) is an inhibitor of JNK. JNK-IN-23 inhibits the proliferation of MDA-MB-231 (GIC50: 30 nM). JNK-IN-23 blocks TNBC metastatic growth in vivo. JNK-IN-23 inhibits the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and pyruvate dehydrogenase complex (PDHC). | |||||||||||||||||||||
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