1016-47-3
Chemical Structure
N-Acetyltryptamine
Synonym(s): N10-Acetyltryptamine; Nb-Acetyltryptamine; Nω-Acetyltryptamine
- CAS No.: 1016-47-3
- Formula:C12H14N2O
- Molecular Weight:202.26
IUPAC Name: N-(2-(1H-indol-3-yl)ethyl)acetamide
InChIKey: NVUGEQAEQJTCIX-UHFFFAOYSA-N
SMILES: CC(NCCC1=CNC2=C1C=CC=C2)=O
Biological Activity: N-Acetyltryptamine (N10-Acetyltryptamine) is a mixed agonist-antagonist of the melatonin receptor. N-Acetyltryptamine inhibits acetylserotonin methyltransferase, blocks the conversion of N-acetylserotonin to melatonin, and inhibits neuronal firing activity in suprachiasmatic nucleus neurons. N-Acetyltryptamine is a physiological constituent of mammalian blood. N-Acetyltryptamine is a metabolite of tryptamine in Bacillus cereus[1][2][3][4][5].
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N-Acetyltryptamine | 97.0% | N-Acetyltryptamine (N10-Acetyltryptamine) is a mixed agonist-antagonist of the melatonin receptor. N-Acetyltryptamine inhibits acetylserotonin methyltransferase, blocks the conversion of N-acetylserotonin to melatonin, and inhibits neuronal firing activity in suprachiasmatic nucleus neurons. N-Acetyltryptamine is a physiological constituent of mammalian blood. N-Acetyltryptamine is a metabolite of tryptamine in Bacillus cereus. | ||||||||||||||||||||
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N-Acetyltryptamine (Standard) | ≥98% | N-Acetyltryptamine (Standard) (N10-Acetyltryptamine (Standard); Nb-Acetyltryptamine (Standard); Nω-Acetyltryptamine (Standard)) is the analytical standard of N-Acetyltryptamine (HY-100908). This product is intended for research and analytical applications. N-Acetyltryptamine (N10-Acetyltryptamine) is a mixed agonist-antagonist of the melatonin receptor. N-Acetyltryptamine inhibits acetylserotonin methyltransferase, blocks the conversion of N-acetylserotonin to melatonin, and inhibits neuronal firing activity in suprachiasmatic nucleus neurons. N-Acetyltryptamine is a physiological constituent of mammalian blood. N-Acetyltryptamine is a metabolite of tryptamine in Bacillus cereus. | ||||||||||||||||||||
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References
- [1]. Backlund PS, et al. Daily Rhythm in Plasma N-acetyltryptamine. Journal of biological rhythms. 2017 Jun;32(3):195-211.
- [2]. Mason R, et al. The electrophysiological effects of melatonin and a putative melatonin antagonist (N-acetyltryptamine) on rat suprachiasmatic neurones in vitro. Neuroscience letters. 1988 Dec 19;95(1-3):296-301.
- [3]. De Angelis J, et al. Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87). The Journal of biological chemistry. 1998 Jan 30;273(5):3045-50. [Content Brief]
- [4]. Hutzinger O. N-acetyltryptamine: an artifact formed during the extraction of tryptamine. Anal Biochem. 1969 Jul;30(1):153-6.
- [5]. Park S, et al. Tryptamine 5-hydroxylase-deficient Sekiguchi rice induces synthesis of 5-hydroxytryptophan and N-acetyltryptamine but decreases melatonin biosynthesis during senescence process of detached leaves. Journal of pineal research. 2012 Mar;52(2):211-6.
