102040-06-2
102040-06-2
Chemical Structure
Cilinaphthalide B
- CAS No.: 102040-06-2
- Formula:C23H22O7
- Molecular Weight:410.42
IUPAC Name: 9-(3,4-dimethoxyphenyl)-4,6,7-trimethoxynaphtho[2,3-c]furan-1(3H)-one
InChIKey: GQAJQAMRZKZXNJ-UHFFFAOYSA-N
SMILES: O=C1OCC=2C(OC)=C3C=C(OC)C(OC)=CC3=C(C=4C=CC(OC)=C(OC)C4)C12
Biological Activity: Cilinaphthalide B is an integrin αIIbβ3 inhibitor and a phthalide derivative that inhibits platelet aggregation by binding to integrin αIIbβ3 and interfering with the conformational changes required for its activation, and it exhibits cytotoxicity against cancer cell lines. Cilinaphthalide B can be used in antiplatelet and anticancer-related research[1][2][3][4].
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Cilinaphthalide B | Cilinaphthalide B is an integrin αIIbβ3 inhibitor and a phthalide derivative that inhibits platelet aggregation by binding to integrin αIIbβ3 and interfering with the conformational changes required for its activation, and it exhibits cytotoxicity against cancer cell lines. Cilinaphthalide B can be used in antiplatelet and anticancer-related research. | |||||||||||||||||||||
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References
- [1]. Wu S, et al. A novel anti-platelet aggregation target of chinensinaphthol methyl ether and neojusticin B obtained from Rostellularia procumbens (L.) Nees. Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1):999-1009.
- [2]. Wu CM, et al. Antiplatelet effect and selective binding to cyclooxygenase (COX) by molecular docking analysis of flavonoids and lignans. International Journal of Molecular Sciences. 2007 Aug 22;8(8):830-41.
- [3]. Day SH, et al. Cytotoxic lignans of Justicia ciliata. Journal of natural products. 1999 Jul;62(7):1056-8. [Content Brief]
- [4]. Guan L, et al. In-Depth Exploration of Chemical Constituents from Justicia procumbens L. Through UHPLC-Q-Exactive Orbitrap Mass Spectrometry. Molecules. 2025 Aug 30;30(17):3554.
