Cytotoxic lignans of Justicia ciliata

  • J Nat Prod. 1999 Jul;62(7):1056-8. doi: 10.1021/np9900167.
S H Day  1 ,  N Y Chiu ,  S J Won ,  C N Lin
Affiliations
  • 1. School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan 807, Republic of China.
PMID: 10425143 DOI: 10.1021/np9900167
Abstract

Two new naturally occurring 1-aryl-2,3-naphthalide Lignans, cilinaphthalide A (1) and cilinaphthalide B (2), and nine known compounds were isolated from the whole plant of Justicia ciliata. Their structures were established by spectral analysis, and their cytotoxic activity was evaluated against several different cell lines. The known compound, justicidin A, showed potent cytotoxic effects against T-24, CaSki, SiHa, HT-3, PLC/PRF/5, and 212 cells in vitro.