1021463-02-4
1021463-02-4
Chemical Structure
C1A
- CAS No.: 1021463-02-4
- Formula:C22H25Cl2N3O4S
- Molecular Weight:498.42
IUPAC Name: (2E,4E)-5-(4-((4-(bis(2-chloroethyl)amino)phenyl)sulfonamido)phenyl)-N-hydroxy-4-methylpenta-2,4-dienamide
InChIKey: HOWUKPILSTXCSC-MASZBAQNSA-N
SMILES: ClCCN(C1=CC=C(C=C1)S(NC2=CC=C(C=C2)/C=C(C)/C=C/C(NO)=O)(=O)=O)CCCl
Biological Activity: C1A is a class I/II HDACs and sirtuin inhibitor with an IC50 of 479 nM for HDAC6. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis in cancer cells[1].
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C1A | C1A is a class I/II HDACs and sirtuin inhibitor with an IC50 of 479 nM for HDAC6. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis in cancer cells. | |||||||||||||||||||||
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References
Keywords
