1021868-80-3
Chemical Structure
L-750667 triHydrochloride
- CAS No.: 1021868-80-3
- Formula:C18H22Cl3IN4
- Molecular Weight:527.66
IUPAC Name: 3-((4-(4-iodophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine trihydrochloride
InChIKey: YOURSPNOEWYAKO-UHFFFAOYSA-N
SMILES: IC1=CC=C(C=C1)N2CCN(CC2)CC3=CNC4=NC=CC=C43.[H]Cl.[H]Cl.[H]Cl
Biological Activity: L-750667 triHydrochloride is a selective antagonist for the D4 dopamine receptor, with a Ki value of 0.51 nM. The radiolabeled form of L-750667, [125I]L-750,667, has a Kd value of 0.16 nM for the D4 receptor. L-750667 triHydrochloride can reverse dopamine-induced inhibition of cAMP accumulation. It can be used to study the distribution and function of D4 dopamine receptors in the central nervous system and has potential applications in the fields of neuroscience and psychiatry[1][2].
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L-750667 triHydrochloride | 99.39% | L-750667 triHydrochloride is a selective antagonist for the D4 dopamine receptor, with a Ki value of 0.51 nM. The radiolabeled form of L-750667, [125I]L-750,667, has a Kd value of 0.16 nM for the D4 receptor. L-750667 triHydrochloride can reverse dopamine-induced inhibition of cAMP accumulation. It can be used to study the distribution and function of D4 dopamine receptors in the central nervous system and has potential applications in the fields of neuroscience and psychiatry. | ||||||||||||||||||||
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- [1]. Staley JK, et al. SPECT imaging with the D(4) receptor antagonist L-750,667 in nonhuman primate brain. Nucl Med Biol. 2000 Aug;27(6):547-56. [Content Brief]
- [2]. Patel S, et al. Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor. Mol Pharmacol. 1996 Dec;50(6):1658-64. [Content Brief]
Keywords
