10308-13-1
Chemical Structure
Cryogenine
Synonym(s): NSC 272693
- CAS. Nr.: 10308-13-1
- Formula:C26H29NO5
- Molecular Weight:435.51
IUPAC Name: (12S,14S,19aR,Z)-36-hydroxy-24,25-dimethoxy-11,13,14,16,17,18,19,19a-octahydro-12H-7-oxa-1(4,2)-quinolizina-2(1,2),3(1,3)-dibenzenacycloheptaphan-4-en-6-one
InChIKey: WCZWUYYJZVBKDZ-VMSBZHFZSA-N
SMILES: COC(C=C([C@@]1([H])N(CCCC2)[C@@]2([H])C[C@@](OC3=O)([H])C1)C(C(C=C(/C=C\3)C=C4)=C4O)=C5)=C5OC
Biological Activity: Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50=424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.
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Cryogenine | Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50=424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis. | |||||||||||||||||||||
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