1034142-33-0
1034142-33-0
Chemical Structure
E-55888
- CAS No.: 1034142-33-0
- Formula:C16H23N3
- Molecular Weight:257.37
IUPAC Name: N,N-dimethyl-2-(3-(1,3,5-trimethyl-1H-pyrazol-4-yl)phenyl)ethan-1-amine
InChIKey: MFUWRMRKXKCSPL-UHFFFAOYSA-N
SMILES: CC1=C(C2=CC(CCN(C)C)=CC=C2)C(C)=NN1C
Biological Activity: E-55888 is a selective and potent agonist of 5-HT7 receptor and 5-HT1A receptor with Ki values of 2.5 nM and 700 nM, respectively, which has analgesic and antinociceptive effects. E-55888 reduces the nociceptive response of Capsaicin (HY-10448) sensitized mice[1][2].
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E-55888 | E-55888 is a selective and potent agonist of 5-HT7 receptor and 5-HT1A receptor with Ki values of 2.5 nM and 700 nM, respectively, which has analgesic and antinociceptive effects. E-55888 reduces the nociceptive response of Capsaicin (HY-10448) sensitized mice. | |||||||||||||||||||||
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References
- [1]. Brenchat A, et al. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. 2009 Feb;141(3):239-247. [Content Brief]
- [2]. Hansen HD, et al. Labeling and preliminary in vivo evaluation of the 5-HT(7) receptor selective agonist [(11)C]E-55888. Bioorg Med Chem Lett. 2015 May 1;25(9):1901-4. [Content Brief]
Keywords
