1037366-37-2
Chemical Structure
DS21412020
- CAS No.: 1037366-37-2
- Formula:C21H23F2N3O5
- Molecular Weight:435.42
IUPAC Name: 7-((3aS,7aS)-3a-aminohexahydropyrano[3,4-c]pyrrol-2(3H)-yl)-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChIKey: QEESVFWVTXIORT-GWXMJYEKSA-N
SMILES: O=C(O)C1=CN(C2=C(C1=O)C=C(C(N3C[C@]4(N)COCC[C@]4(C3)[H])=C2OC)F)[C@H]5[C@H](C5)F
Biological Activity: DS21412020 is a fluoroquinolone antibacterial agent. DS21412020 inhibits bacterial DNA gyrase (GyrA) and topoisomerase IV, leading to DNA breaks. DS21412020 exhibits significant activity against Gram-positive bacteria such as Staphylococcus aureus (MIC = 0.006 μg/mL), Streptococcus pneumoniae (MIC = 0.05 μg/mL), and Methicillin (HY-121544)-resistant Staphylococcus aureus (MIC = 0.2 μg/mL), and Gram-negative bacteria such as Escherichia coli (MIC = 0.006 μg/mL) and Pseudomonas aeruginosa (MIC = 0.78 μg/mL). DS21412020 significantly reduces bacterial load in mouse pneumonia and MRSA infection models. DS21412020 can be used in the development of next-generation quinolone antibiotics[1].
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DS21412020 | DS21412020 is a fluoroquinolone antibacterial agent. DS21412020 inhibits bacterial DNA gyrase (GyrA) and topoisomerase IV, leading to DNA breaks. DS21412020 exhibits significant activity against Gram-positive bacteria such as Staphylococcus aureus (MIC = 0.006 μg/mL), Streptococcus pneumoniae (MIC = 0.05 μg/mL), and Methicillin (HY-121544)-resistant Staphylococcus aureus (MIC = 0.2 μg/mL), and Gram-negative bacteria such as Escherichia coli (MIC = 0.006 μg/mL) and Pseudomonas aeruginosa (MIC = 0.78 μg/mL). DS21412020 significantly reduces bacterial load in mouse pneumonia and MRSA infection models. DS21412020 can be used in the development of next-generation quinolone antibiotics. | |||||||||||||||||||||
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References
- [1]. Odagiri T, et al. Design, Synthesis, and Biological Evaluation of Novel 7-[(3 aS,7 aS)-3 a-Aminohexahydropyrano[3,4- c]pyrrol-2(3 H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens. J Med Chem. 2018 Aug 23;61(16):7234-7244. doi: 10.1021/acs.jmedchem.8b00644. Epub 2018 Aug 8. [Content Brief]
