105102-21-4
105102-21-4
Chemical Structure
Torbafylline
Synonym(s): HWA 448
- CAS No.: 105102-21-4
- Formula:C16H26N4O4
- Molecular Weight:338.40
InChIKey: QSXXLDDWVCEBFP-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C(N1CCCCC(C)(C)O)=O)N=CN2COCC
Biological Activity: Torbafylline is a PDE inhibitor. Torbafylline mitigates protein breakdown in rat skeletal muscle following burns by activating the PDE4/cAMP/EPAC/PI3K/Akt signaling pathway. Torbafylline suppresses the increased ubiquitin-proteasome-dependent protein degradation observed in the skeletal muscles of rats susceptible to cancer and sepsis[1].
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Torbafylline | Torbafylline is a PDE inhibitor. Torbafylline mitigates protein breakdown in rat skeletal muscle following burns by activating the PDE4/cAMP/EPAC/PI3K/Akt signaling pathway. Torbafylline suppresses the increased ubiquitin-proteasome-dependent protein degradation observed in the skeletal muscles of rats susceptible to cancer and sepsis. | |||||||||||||||||||||
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