106400-18-4
106400-18-4
Chemical Structure
LY243246
Synonym(s): (6S)-DDATHF
- CAS. Nr.: 106400-18-4
- Formula:C21H25N5O6
- Molecular Weight:443.45
IUPAC Name: (4-(2-((S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl)benzoyl)-L-glutamic acid
InChIKey: ZUQBAQVRAURMCL-WFASDCNBSA-N
SMILES: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CC[C@H](CN2)CC3=C2NC(N)=NC3=O)C=C1)=O
Biological Activity: LY243246 ((6S)-DDATHF), the 6S diastereomer of DDATHF, is a potent competitive inhibitor of 5’-phosphoribosylglycinamide formyltransferase (GAR transformylase). 6R- and 6S-diastereomers of DDATHF are remarkably similar and equiactive antimetabolites inhibitory to de novo purine synthesis[1].
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LY243246 | LY243246 ((6S)-DDATHF), the 6S diastereomer of DDATHF, is a potent competitive inhibitor of 5’-phosphoribosylglycinamide formyltransferase (GAR transformylase). 6R- and 6S-diastereomers of DDATHF are remarkably similar and equiactive antimetabolites inhibitory to de novo purine synthesis. | |||||||||||||||||||||
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