107889-31-6
Chemical Structure
LY256548
Synonym(s): LY25684
- CAS No.: 107889-31-6
- Formula:C19H27NO2S
- Molecular Weight:333.49
IUPAC Name: (Z)-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-3-methylthiazolidin-4-one
InChIKey: IXCMEASJCGKKQS-GDNBJRDFSA-N
SMILES: O=C1N(CS/C1=C\C2=CC(C(C)(C)C)=C(C(C(C)(C)C)=C2)O)C
Biological Activity: LY256548 (LY25648) is an orally available anti-ischemic and anti-inflammatory compound with central nervous system activity. LY256548 is an inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and COX, and inhibits A23187 (HY-N6687)-stimulated leukotriene B4 production. LY256548 inhibits bone damage and paw swelling in the rat Freund's complete adjuvant-induced arthritis (FCA) model[1][2].
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LY256548 | LY256548 (LY25648) is an orally available anti-ischemic and anti-inflammatory compound with central nervous system activity. LY256548 is an inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and COX, and inhibits A23187 (HY-N6687)-stimulated leukotriene B4 production. LY256548 inhibits bone damage and paw swelling in the rat Freund's complete adjuvant-induced arthritis (FCA) model. | |||||||||||||||||||||
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- [1]. Ruterbories KJ, et al. Pharmacokinetics of a novel butylated hydroxytoluene-thiazolidinone CNS antiischemic agent LY256548 in rats, mice, dogs, and monkeys. Drug Metab Dispos. 1990 Sep-Oct;18(5):674-9. [Content Brief]
- [2]. Panetta JA, et al. The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2. [Content Brief]
Keywords
