108395-15-9
108395-15-9
Chemical Structure
2-Ketoglutaric acid-13C
Synonym(s): Alpha-Ketoglutaric acid-13C
- CAS No.: 108395-15-9
- Formula:C413CH6O5
- Molecular Weight:147.09
IUPAC Name: 2-oxopentanedioic-1-13C acid
InChIKey: KPGXRSRHYNQIFN-HOSYLAQJSA-N
SMILES: OC(CCC([13C](O)=O)=O)=O
Biological Activity: 2-Ketoglutaric acid-13C (Alpha-Ketoglutaric acid-13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636)[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Ketoglutaric acid-13C | 2-Ketoglutaric acid-13C (Alpha-Ketoglutaric acid-13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). | |||||||||||||||||||||
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2-Ketoglutaric acid (Standard) | 99.53% | 2-Ketoglutaric acid (Standard) (Alpha-Ketoglutaric acid (Standard)) is the analytical standard of 2-Ketoglutaric acid (HY-W013636). This product is intended for research and analytical applications. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). | ||||||||||||||||||||
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2-Ketoglutaric acid-d4 | 2-Ketoglutaric acid-d4 (Alpha-Ketoglutaric acid-d4) is the deuterium labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid Sodium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM). | |||||||||||||||||||||
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2-Ketoglutaric acid-d6 | 98.62% | 2-Ketoglutaric acid-d6 (Alpha-Ketoglutaric acid-d6) is the deuterium labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). | ||||||||||||||||||||
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2-Ketoglutaric acid-13C5 | 99.92% | 2-Ketoglutaric acid-13C5 (Alpha-Ketoglutaric acid-13C5) is a 13C labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). | ||||||||||||||||||||
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2-Ketoglutaric acid | 99.68% | 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [Content Brief]
- [2]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [Content Brief]
- [3]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662. [Content Brief]
