1092689-33-2
1092689-33-2
Chemical Structure
Tetrazine-Amine
Synonym(s): (4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine; Tetrazine-NH2
- CAS No.: 1092689-33-2
- Formula:C9H9N5
- Molecular Weight:187.20
IUPAC Name: (4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine
InChIKey: JGCOJRPYFRRONJ-UHFFFAOYSA-N
SMILES: NCC1=CC=C(C2=NN=CN=N2)C=C1
Biological Activity: Tetrazine-Amine ((4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine) is a tetrazine linker that can be used to covalently label live cells through a cycloaddition[1][2]. Tetrazine-Amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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Tetrazine-Amine | Tetrazine-Amine ((4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine) is a tetrazine linker that can be used to covalently label live cells through a cycloaddition. Tetrazine-Amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. | |||||||||||||||||||||
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References
- [1]. Devaraj NK, et, al. Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl. 2009;48(38):7013-6. [Content Brief]
- [2]. Devaraj NK, et, al. Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem. 2008 Dec;19(12):2297-9. [Content Brief]
