1094030-07-5
Chemical Structure
3-Hydroxyhericenone F
- CAS No.: 1094030-07-5
- Formula:C35H54O7
- Molecular Weight:586.81
IUPAC Name: ((S)-7-formyl-2-((R)-2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-4-methoxy-2,3-dihydrobenzofuran-6-yl)methyl palmitate
InChIKey: KSRGDCWFRBIFGR-HJIQQCSTSA-N
SMILES: C(=O)C1=C2C(=C(OC)C=C1COC(CCCCCCCCCCCCCCC)=O)C[C@@]([C@](CC(C=C(C)C)=O)(C)O)(O2)[H]
Biological Activity: 3-Hydroxyhericenone F is a neuroprotective agent. Hydroxyhericenone F protects cells against NaN3-induced toxicity, ultrastructural changes, and alterations in mitochondrial respiratory chain complexes. 3-Hydroxyhericenone F decreases intracellular ROS and calcium levels, increases mitochondrial membrane potential and ATP levels, attenuates NaN3 -induced changes in apoptosis-related proteins, and protects neuronal cells from endoplasmic reticulum stress-dependent cell death. 3-Hydroxyhericenone F can be used in research related to cancer, Alzheimer's disease, and neurodegenerative diseases[1][2][3].
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3-Hydroxyhericenone F | 3-Hydroxyhericenone F is a neuroprotective agent. Hydroxyhericenone F protects cells against NaN3-induced toxicity, ultrastructural changes, and alterations in mitochondrial respiratory chain complexes. 3-Hydroxyhericenone F decreases intracellular ROS and calcium levels, increases mitochondrial membrane potential and ATP levels, attenuates NaN3 -induced changes in apoptosis-related proteins, and protects neuronal cells from endoplasmic reticulum stress-dependent cell death. 3-Hydroxyhericenone F can be used in research related to cancer, Alzheimer's disease, and neurodegenerative diseases. | |||||||||||||||||||||
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References
- [1]. Diling C, et al. Docking studies and biological evaluation of a potential β-secretase inhibitor of 3-hydroxyhericenone F from Hericium erinaceus. Frontiers in pharmacology. 2017 May 12;8:219.
- [2]. Ueda K, et al. An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum. Bioorganic & medicinal chemistry. 2008 Nov 01;16(21):9467-70.
- [3]. Kobayashi S, et al. Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A− C and their derivatives. Tetrahedron Letters. 2018 May 2;59(18):1733-6.
