110374-16-8
Chemical Structure
4-Desmethoxy Omeprazole
- CAS No.: 110374-16-8
- Formula:C16H17N3O2S
- Molecular Weight:315.39
IUPAC Name: 2-(((3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-6-methoxy-1H-benzo[d]imidazole
InChIKey: ZMXZYNHJPJEPAE-UHFFFAOYSA-N
SMILES: COC1=CC=C2N=C(S(CC3=NC=C(C)C=C3C)=O)NC2=C1
Biological Activity: 4-Desmethoxy Omeprazole is a metabolite of Omeprazole (HY-B0113) and an impurity in its preparation process. Omeprazole is an orally active H+,K+-ATPase inhibitor and also a proton pump inhibitor. Omeprazole competitively inhibits the activity of CYP2C19, CYP3A4, and CYP2C9. Omeprazole inhibits gastric acid secretion and can be used for the treatment of acid-related gastrointestinal disorders. Omeprazole also has neuroprotective and antibacterial effects[1][2][3][4].
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4-Desmethoxy Omeprazole | 98.99% | 4-Desmethoxy Omeprazole is a metabolite of Omeprazole (HY-B0113) and an impurity in its preparation process. Omeprazole is an orally active H+,K+-ATPase inhibitor and also a proton pump inhibitor. Omeprazole competitively inhibits the activity of CYP2C19, CYP3A4, and CYP2C9. Omeprazole inhibits gastric acid secretion and can be used for the treatment of acid-related gastrointestinal disorders. Omeprazole also has neuroprotective and antibacterial effects. | ||||||||||||||||||||
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4-Desmethoxy Omeprazole (Standard) | ≥98% | 4-Desmethoxy Omeprazole Standard is the analytical standard of 4-Desmethoxy Omeprazole (HY-135111). This product is intended for research and analytical applications. 4-Desmethoxy Omeprazole is a metabolite of Omeprazole (HY-B0113) and an impurity in its preparation process. Omeprazole is an orally active H+,K+-ATPase inhibitor and also a proton pump inhibitor. Omeprazole competitively inhibits the activity of CYP2C19, CYP3A4, and CYP2C9. Omeprazole inhibits gastric acid secretion and can be used for the treatment of acid-related gastrointestinal disorders. Omeprazole also has neuroprotective and antibacterial effects. | ||||||||||||||||||||
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4-Desmethoxy Omeprazole-d3 | 4-Desmethoxy Omeprazole-d3 is the deuterated-labeled 4-Desmethoxy Omeprazole (HY-135111). 4-Desmethoxy Omeprazole is a metabolite of Omeprazole (HY-B0113) and an impurity in its preparation process. Omeprazole is an orally active H+,K+-ATPase inhibitor and also a proton pump inhibitor. Omeprazole competitively inhibits the activity of CYP2C19, CYP3A4, and CYP2C9. Omeprazole inhibits gastric acid secretion and can be used for the treatment of acid-related gastrointestinal disorders. Omeprazole also has neuroprotective and antibacterial effects. | |||||||||||||||||||||
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References
- [1]. Hernández F, et al. Retrospective LC-QTOF-MS analysis searching for pharmaceutical metabolites in urban wastewater. Journal of separation science. 2011 Dec;34(24):3517-26.
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[2]. Richardson SD, et
al. Water analysis: emerging contaminants and current issues. Analytical chemistry. 2014 Mar 18;86(6):2813-48. - [3]. Bellia GF, et al. Analysis of omeprazole and esomeprazole obtained from traditional pharmacies and unlicensed internet websites using Raman spectroscopy, 1H-NMR and chemometric analysis. Vibrational Spectroscopy. 2020 Jan 1;106:102996.
- [4]. Bade R, et al. Suspect screening of large numbers of emerging contaminants in environmental waters using artificial neural networks for chromatographic retention time prediction and high resolution mass spectrometry data analysis. The Science of the total environment. 2015 Dec 15;538:934-41.
