1108748-12-4
1108748-12-4
Chemical Structure
LY593093
- CAS No.: 1108748-12-4
- Formula:C32H30FN3O2
- Molecular Weight:507.60
IUPAC Name: N-((1R,2R)-6-(((E)-1-((4-fluorobenzyl)(methyl)amino)ethylidene)amino)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-[1,1'-biphenyl]-4-carboxamide
InChIKey: KOQVBYSCBCRVQJ-SVUXJTORSA-N
SMILES: O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[C@@H]3C4=CC(/N=C(C)/N(C)CC5=CC=C(C=C5)F)=CC=C4C[C@H]3O
Biological Activity: LY593093 is an orally active, selective, partial, orthosteric M1AChR agonist. LY593093 stimulates hippocampal phosphoinositide hydrolysis. LY593093 is used in research on Alzheimer's disease and schizophrenia[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LY593093 | 98.82% | LY593093 is an orally active, selective, partial, orthosteric M1AChR agonist. LY593093 stimulates hippocampal phosphoinositide hydrolysis. LY593093 is used in research on Alzheimer's disease and schizophrenia. | ||||||||||||||||||||
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References
- [1]. Liu B, et al. Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl] arylamides as selective and potent muscarinic M1 agonists[J]. Bioorganic & Medicinal Chemistry Letters, 2015, 25(19): 4158-4163.
- [2]. Watt ML, et al. Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist. J Pharmacol Exp Ther. 2011 Aug;338(2):622-32.
- [3]. Volpato D, et al. Designing Hybrids Targeting the Cholinergic System by Modulating the Muscarinic and Nicotinic Receptors: A Concept to Treat Alzheimer's Disease. Molecules. 2018 Dec 7;23(12):3230.
- [4]. Felder CC, et al. Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases. Neuropharmacology. 2018 Jul 1;136(Pt C):449-458. [Content Brief]
