1123071-24-8
Chemical Structure
D-Trp-Aib
- CAS No.: 1123071-24-8
- Formula:C15H19N3O3
- Molecular Weight:289.34
IUPAC Name: (R)-2-(2-amino-3-(1H-indol-3-yl)propanamido)-2-methylpropanoic acid
InChIKey: SHAXSXUDZJSSCN-LLVKDONJSA-N
SMILES: C([C@H](C(NC(C(O)=O)(C)C)=O)N)C=1C=2C(NC1)=CC=CC2
Biological Activity: D-Trp-Aib is a dipeptide and amyloid-β inhibitor with a Kd of 29.6 nM. D-Trp-Aib triggers formation of non-toxic, non-β-sheet, amorphous amyloid β clusters from misfolded amyloid β monomers and toxic amyloid β oligomers, and reduces toxic amyloid β1-42 deposits. D-Trp-Aib inhibits amyloid fibril formation of α‑synuclein, IAPP and calcitonin. D-Trp-Aib can be used for the research of Alzheimer's disease[1][2].
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D-Trp-Aib | D-Trp-Aib is a dipeptide and amyloid-β inhibitor with a Kd of 29.6 nM. D-Trp-Aib triggers formation of non-toxic, non-β-sheet, amorphous amyloid β clusters from misfolded amyloid β monomers and toxic amyloid β oligomers, and reduces toxic amyloid β1-42 deposits. D-Trp-Aib inhibits amyloid fibril formation of α‑synuclein, IAPP and calcitonin. D-Trp-Aib can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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