112668-45-8
112668-45-8
Chemical Structure
2-Hydroxy Imiquimod
Synonym(s): R-842
- CAS No.: 112668-45-8
- Formula:C14H16N4O
- Molecular Weight:256.30
IUPAC Name: 1-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
InChIKey: CNBOKXFMODKQCT-UHFFFAOYSA-N
SMILES: OC(C)(CN1C=NC2=C1C3=C(C=CC=C3)N=C2N)C
Biological Activity: 2-Hydroxy Imiquimod (R-842), a hydroxylated metabolite of Imiquimod (HY-B0180), is an immunomodulating agent. 2-Hydroxy Imiquimod can induce IFN-α, TNF-α, IL-1, IL-6 and IL-8 in human blood cells. 2-Hydroxy Imiquimod exhibits antivirus and antitumor activities. 2-Hydroxy Imiquimod can be used for the researches of cancer, infection and immunology[1][2].
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2-Hydroxy Imiquimod | 2-Hydroxy Imiquimod (R-842), a hydroxylated metabolite of Imiquimod (HY-B0180), is an immunomodulating agent. 2-Hydroxy Imiquimod can induce IFN-α, TNF-α, IL-1, IL-6 and IL-8 in human blood cells. 2-Hydroxy Imiquimod exhibits antivirus and antitumor activities. 2-Hydroxy Imiquimod can be used for the researches of cancer, infection and immunology. | |||||||||||||||||||||
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Imiquimod impurity 1-d6 | Imiquimod impurity 1-d6 is the deuterium labeled Imiquimod impurity 1. | |||||||||||||||||||||
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References
- [1]. Weeks CE, et al. Induction of interferon and other cytokines by imiquimod and its hydroxylated metabolite R-842 in human blood cells in vitro. J Interferon Res. 1994 Apr;14(2):81-5. [Content Brief]
- [2]. Imbertson LM, et al. Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463. J Invest Dermatol. 1998 May;110(5):734-9. [Content Brief]
