112806-33-4
112806-33-4
Chemical Structure
Amitriptyline N-β-D-glucuronide
- CAS No.: 112806-33-4
- Formula:C26H31NO6
- Molecular Weight:453.53
IUPAC Name: (2S,3S,4S,5R,6R)-6-((3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propyl)dimethylammonio)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
InChIKey: WXMXRAPAGYPAJI-ARXROMJUSA-N
SMILES: C[N+](C)([C@@H]([C@@H]([C@H]1O)O)O[C@@H]([C@H]1O)C([O-])=O)CC/C=C2C3=CC=CC=C3CCC4=CC=CC=C\24
Biological Activity: Amitriptyline N-β-D-glucuronide is an N-glucuronide metabolite of Amitriptyline (HY-B0527). Amitriptyline is an antidepressant. Amitriptyline can be used in the study of fibromyalgia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Amitriptyline N-β-D-glucuronide | 97.37% | Amitriptyline N-β-D-glucuronide is an N-glucuronide metabolite of Amitriptyline (HY-B0527). Amitriptyline is an antidepressant. Amitriptyline can be used in the study of fibromyalgia. | ||||||||||||||||||||
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Amitriptyline-N-glucuronide-d3 | 97.0% | Amitriptyline-N-glucuronide-d3 is the deuterium labeled Amitriptyline-N-glucuronide. | ||||||||||||||||||||
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References
- [1]. Lu D, et al. Highly selective N-glucuronidation of four piperazine-containing drugs by UDP-glucuronosyltransferase 2B10. Expert Opinion on Drug Metabolism & Toxicology. 2018 Sep 2;14(9):989-98.
- [2]. Lu D, et al. N-glucuronidation catalyzed by UGT1A4 and UGT2B10 in human liver microsomes: Assay optimization and substrate identification. Journal of pharmaceutical and biomedical analysis. 2017 Oct 25;145:692-703.
- [3]. Kim Lawson. A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia. Biomedicines. 2017 Jun; 5(2): 24. [Content Brief]
