1128096-64-9
Chemical Structure
JNK-9L
- CAS No.: 1128096-64-9
- Formula:C26H27FN8O2
- Molecular Weight:502.54
IUPAC Name: 4-(3-fluoro-5-morpholinophenyl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine
InChIKey: AHMHIFXJPSHHPH-UHFFFAOYSA-N
SMILES: FC1=CC(C2=NC(NC(C=C3)=CC=C3N4C=NC(N5CCOCC5)=N4)=NC=C2)=CC(N6CCOCC6)=C1
Biological Activity: JNK-9L (Compound 9l) is a BBB-penetrable and ATP-competitive JNK inhibitor with IC50s of 0.099 and 0.148 μM for JNK1 and JNK3, respectively. JNK-9L significantly inhibits c-jun phosphorylation and Streptozotocin (HY-13753)-induced ROS generation with an IC50 of 0.8 nM. JNK-9L can be used for neurodegenerative disorders like Parkinson’s disease research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JNK-9L | 98.06% | JNK-9L (Compound 9l) is a BBB-penetrable and ATP-competitive JNK inhibitor with IC50s of 0.099 and 0.148 μM for JNK1 and JNK3, respectively. JNK-9L significantly inhibits c-jun phosphorylation and Streptozotocin (HY-13753)-induced ROS generation with an IC50 of 0.8 nM. JNK-9L can be used for neurodegenerative disorders like Parkinson’s disease research. | ||||||||||||||||||||
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